TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling.
Identifieur interne : 000473 ( Main/Exploration ); précédent : 000472; suivant : 000474TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling.
Auteurs : Natsumi Kawasaki [Japon] ; Kazunobu Isogaya [Japon] ; Shingo Dan [Japon] ; Takao Yamori [Japon] ; Hiroshi Takano [Japon] ; Ryoji Yao [Japon] ; Yasuyuki Morishita [Japon] ; Luna Taguchi [Japon] ; Masato Morikawa [Japon, Suède] ; Carl-Henrik Heldin [Suède] ; Tetsuo Noda [Japon] ; Shogo Ehata [Japon] ; Kohei Miyazono [Japon, Suède] ; Daizo Koinuma [Japon]Source :
- Cell discovery [ 2056-5968 ] ; 2018.
Abstract
The mammalian target of rapamycin (mTOR) pathway is commonly activated in human cancers. The activity of mTOR complex 1 (mTORC1) signaling is supported by the intracellular positioning of cellular compartments and vesicle trafficking, regulated by Rab GTPases. Here we showed that tuftelin 1 (TUFT1) was involved in the activation of mTORC1 through modulating the Rab GTPase-regulated process. TUFT1 promoted tumor growth and metastasis. Consistently, the expression of TUFT1 correlated with poor prognosis in lung, breast and gastric cancers. Mechanistically, TUFT1 physically interacted with RABGAP1, thereby modulating intracellular lysosomal positioning and vesicular trafficking, and promoted mTORC1 signaling. In addition, expression of TUFT1 predicted sensitivity to perifosine, an alkylphospholipid that alters the composition of lipid rafts. Perifosine treatment altered the positioning and trafficking of cellular compartments to inhibit mTORC1. Our observations indicate that TUFT1 is a key regulator of the mTORC1 pathway and suggest that it is a promising therapeutic target or a biomarker for tumor progression.
DOI: 10.1038/s41421-017-0001-2
PubMed: 29423269
PubMed Central: PMC5798889
Affiliations:
- Japon, Suède
- East Middle Sweden, Région de Kantō, Svealand
- Tokyo, Uppsala
- Université d'Uppsala, Université de Tokyo
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School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author><author><name sortKey="Taguchi, Luna" sort="Taguchi, Luna" uniqKey="Taguchi L" first="Luna" last="Taguchi">Luna Taguchi</name><affiliation wicri:level="4"><nlm:affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author><author><name sortKey="Morikawa, Masato" sort="Morikawa, Masato" uniqKey="Morikawa M" first="Masato" last="Morikawa">Masato Morikawa</name><affiliation wicri:level="4"><nlm:affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>4Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>4Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala</wicri:regionArea><orgName type="university">Université 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Microbiology, Science for Life Laboratory, Box 582, Uppsala University, SE-751 23 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>5Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Uppsala University, SE-751 23 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Noda, Tetsuo" sort="Noda, Tetsuo" uniqKey="Noda T" first="Tetsuo" last="Noda">Tetsuo Noda</name><affiliation wicri:level="3"><nlm:affiliation>3Division of Cell Biology and Director's Room, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>3Division of Cell Biology and Director's Room, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Ehata, Shogo" sort="Ehata, Shogo" uniqKey="Ehata S" first="Shogo" last="Ehata">Shogo Ehata</name><affiliation wicri:level="4"><nlm:affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author><author><name sortKey="Miyazono, Kohei" sort="Miyazono, Kohei" uniqKey="Miyazono K" first="Kohei" last="Miyazono">Kohei Miyazono</name><affiliation wicri:level="4"><nlm:affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>4Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>4Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Koinuma, Daizo" sort="Koinuma, Daizo" uniqKey="Koinuma D" first="Daizo" last="Koinuma">Daizo Koinuma</name><affiliation wicri:level="4"><nlm:affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29423269</idno><idno type="pmid">29423269</idno><idno type="doi">10.1038/s41421-017-0001-2</idno><idno type="pmc">PMC5798889</idno><idno type="wicri:Area/Main/Corpus">000618</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000618</idno><idno type="wicri:Area/Main/Curation">000618</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000618</idno><idno type="wicri:Area/Main/Exploration">000618</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling.</title><author><name sortKey="Kawasaki, Natsumi" sort="Kawasaki, Natsumi" uniqKey="Kawasaki N" first="Natsumi" last="Kawasaki">Natsumi Kawasaki</name><affiliation wicri:level="4"><nlm:affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author><author><name sortKey="Isogaya, Kazunobu" sort="Isogaya, Kazunobu" uniqKey="Isogaya K" first="Kazunobu" last="Isogaya">Kazunobu Isogaya</name><affiliation wicri:level="4"><nlm:affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author><author><name sortKey="Dan, Shingo" sort="Dan, Shingo" uniqKey="Dan S" first="Shingo" last="Dan">Shingo Dan</name><affiliation wicri:level="3"><nlm:affiliation>2Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, 135-8550 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>2Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Yamori, Takao" sort="Yamori, Takao" uniqKey="Yamori T" first="Takao" last="Yamori">Takao Yamori</name><affiliation wicri:level="3"><nlm:affiliation>2Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, 135-8550 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>2Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Present Address: Center for Product Evaluation, Pharmaceuticals and Medical Device Agency, Tokyo, 100-0013 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Present Address: Center for Product Evaluation, Pharmaceuticals and Medical Device Agency, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Takano, Hiroshi" sort="Takano, Hiroshi" uniqKey="Takano H" first="Hiroshi" last="Takano">Hiroshi Takano</name><affiliation wicri:level="3"><nlm:affiliation>3Division of Cell Biology and Director's Room, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>3Division of Cell Biology and Director's Room, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Yao, Ryoji" sort="Yao, Ryoji" uniqKey="Yao R" first="Ryoji" last="Yao">Ryoji Yao</name><affiliation wicri:level="3"><nlm:affiliation>3Division of Cell Biology and Director's Room, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>3Division of Cell Biology and Director's Room, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Morishita, Yasuyuki" sort="Morishita, Yasuyuki" uniqKey="Morishita Y" first="Yasuyuki" last="Morishita">Yasuyuki Morishita</name><affiliation wicri:level="4"><nlm:affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author><author><name sortKey="Taguchi, Luna" sort="Taguchi, Luna" uniqKey="Taguchi L" first="Luna" last="Taguchi">Luna Taguchi</name><affiliation wicri:level="4"><nlm:affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author><author><name sortKey="Morikawa, Masato" sort="Morikawa, Masato" uniqKey="Morikawa M" first="Masato" last="Morikawa">Masato Morikawa</name><affiliation wicri:level="4"><nlm:affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>4Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>4Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Heldin, Carl Henrik" sort="Heldin, Carl Henrik" uniqKey="Heldin C" first="Carl-Henrik" last="Heldin">Carl-Henrik Heldin</name><affiliation wicri:level="4"><nlm:affiliation>4Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>4Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>5Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Uppsala University, SE-751 23 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>5Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Uppsala University, SE-751 23 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Noda, Tetsuo" sort="Noda, Tetsuo" uniqKey="Noda T" first="Tetsuo" last="Noda">Tetsuo Noda</name><affiliation wicri:level="3"><nlm:affiliation>3Division of Cell Biology and Director's Room, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>3Division of Cell Biology and Director's Room, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Ehata, Shogo" sort="Ehata, Shogo" uniqKey="Ehata S" first="Shogo" last="Ehata">Shogo Ehata</name><affiliation wicri:level="4"><nlm:affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author><author><name sortKey="Miyazono, Kohei" sort="Miyazono, Kohei" uniqKey="Miyazono K" first="Kohei" last="Miyazono">Kohei Miyazono</name><affiliation wicri:level="4"><nlm:affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation><affiliation wicri:level="4"><nlm:affiliation>4Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>4Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Koinuma, Daizo" sort="Koinuma, Daizo" uniqKey="Koinuma D" first="Daizo" last="Koinuma">Daizo Koinuma</name><affiliation wicri:level="4"><nlm:affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author></analytic><series><title level="j">Cell discovery</title><idno type="ISSN">2056-5968</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The mammalian target of rapamycin (mTOR) pathway is commonly activated in human cancers. The activity of mTOR complex 1 (mTORC1) signaling is supported by the intracellular positioning of cellular compartments and vesicle trafficking, regulated by Rab GTPases. Here we showed that tuftelin 1 (TUFT1) was involved in the activation of mTORC1 through modulating the Rab GTPase-regulated process. TUFT1 promoted tumor growth and metastasis. Consistently, the expression of TUFT1 correlated with poor prognosis in lung, breast and gastric cancers. Mechanistically, TUFT1 physically interacted with RABGAP1, thereby modulating intracellular lysosomal positioning and vesicular trafficking, and promoted mTORC1 signaling. In addition, expression of <i>TUFT1</i> predicted sensitivity to perifosine, an alkylphospholipid that alters the composition of lipid rafts. Perifosine treatment altered the positioning and trafficking of cellular compartments to inhibit mTORC1. Our observations indicate that TUFT1 is a key regulator of the mTORC1 pathway and suggest that it is a promising therapeutic target or a biomarker for tumor progression.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">29423269</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>01</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2056-5968</ISSN><JournalIssue CitedMedium="Print"><Volume>4</Volume><PubDate><Year>2018</Year></PubDate></JournalIssue><Title>Cell discovery</Title><ISOAbbreviation>Cell Discov</ISOAbbreviation></Journal><ArticleTitle>TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling.</ArticleTitle><Pagination><MedlinePgn>1</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41421-017-0001-2</ELocationID><Abstract><AbstractText>The mammalian target of rapamycin (mTOR) pathway is commonly activated in human cancers. The activity of mTOR complex 1 (mTORC1) signaling is supported by the intracellular positioning of cellular compartments and vesicle trafficking, regulated by Rab GTPases. Here we showed that tuftelin 1 (TUFT1) was involved in the activation of mTORC1 through modulating the Rab GTPase-regulated process. TUFT1 promoted tumor growth and metastasis. Consistently, the expression of TUFT1 correlated with poor prognosis in lung, breast and gastric cancers. Mechanistically, TUFT1 physically interacted with RABGAP1, thereby modulating intracellular lysosomal positioning and vesicular trafficking, and promoted mTORC1 signaling. In addition, expression of <i>TUFT1</i> predicted sensitivity to perifosine, an alkylphospholipid that alters the composition of lipid rafts. Perifosine treatment altered the positioning and trafficking of cellular compartments to inhibit mTORC1. Our observations indicate that TUFT1 is a key regulator of the mTORC1 pathway and suggest that it is a promising therapeutic target or a biomarker for tumor progression.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kawasaki</LastName><ForeName>Natsumi</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</Affiliation><Identifier Source="ISNI">0000 0001 2151 536X</Identifier><Identifier Source="GRID">grid.26999.3d</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Isogaya</LastName><ForeName>Kazunobu</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</Affiliation><Identifier Source="ISNI">0000 0001 2151 536X</Identifier><Identifier Source="GRID">grid.26999.3d</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dan</LastName><ForeName>Shingo</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>2Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, 135-8550 Japan.</Affiliation><Identifier Source="ISNI">0000 0001 0037 4131</Identifier><Identifier Source="GRID">grid.410807.a</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yamori</LastName><ForeName>Takao</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>2Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, 135-8550 Japan.</Affiliation><Identifier Source="ISNI">0000 0001 0037 4131</Identifier><Identifier Source="GRID">grid.410807.a</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>Present Address: Center for Product Evaluation, Pharmaceuticals and Medical Device Agency, Tokyo, 100-0013 Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Takano</LastName><ForeName>Hiroshi</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>3Division of Cell Biology and Director's Room, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, 113-0033 Japan.</Affiliation><Identifier Source="ISNI">0000 0001 0037 4131</Identifier><Identifier Source="GRID">grid.410807.a</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yao</LastName><ForeName>Ryoji</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>3Division of Cell Biology and Director's Room, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, 113-0033 Japan.</Affiliation><Identifier Source="ISNI">0000 0001 0037 4131</Identifier><Identifier Source="GRID">grid.410807.a</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morishita</LastName><ForeName>Yasuyuki</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</Affiliation><Identifier Source="ISNI">0000 0001 2151 536X</Identifier><Identifier Source="GRID">grid.26999.3d</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taguchi</LastName><ForeName>Luna</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</Affiliation><Identifier Source="ISNI">0000 0001 2151 536X</Identifier><Identifier Source="GRID">grid.26999.3d</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morikawa</LastName><ForeName>Masato</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-6191-7176</Identifier><AffiliationInfo><Affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</Affiliation><Identifier Source="ISNI">0000 0001 2151 536X</Identifier><Identifier Source="GRID">grid.26999.3d</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>4Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala, Sweden.</Affiliation><Identifier Source="ISNI">0000 0004 1936 9457</Identifier><Identifier Source="GRID">grid.8993.b</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heldin</LastName><ForeName>Carl-Henrik</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>4Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala, Sweden.</Affiliation><Identifier Source="ISNI">0000 0004 1936 9457</Identifier><Identifier Source="GRID">grid.8993.b</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>5Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Uppsala University, SE-751 23 Uppsala, Sweden.</Affiliation><Identifier Source="ISNI">0000 0004 1936 9457</Identifier><Identifier Source="GRID">grid.8993.b</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Noda</LastName><ForeName>Tetsuo</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>3Division of Cell Biology and Director's Room, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, 113-0033 Japan.</Affiliation><Identifier Source="ISNI">0000 0001 0037 4131</Identifier><Identifier Source="GRID">grid.410807.a</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ehata</LastName><ForeName>Shogo</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</Affiliation><Identifier Source="ISNI">0000 0001 2151 536X</Identifier><Identifier Source="GRID">grid.26999.3d</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miyazono</LastName><ForeName>Kohei</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</Affiliation><Identifier Source="ISNI">0000 0001 2151 536X</Identifier><Identifier Source="GRID">grid.26999.3d</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>4Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, SE-751 24 Uppsala, Sweden.</Affiliation><Identifier Source="ISNI">0000 0004 1936 9457</Identifier><Identifier Source="GRID">grid.8993.b</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koinuma</LastName><ForeName>Daizo</ForeName><Initials>D</Initials><Identifier Source="ORCID">0000-0001-5611-2122</Identifier><AffiliationInfo><Affiliation>1Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.</Affiliation><Identifier Source="ISNI">0000 0001 2151 536X</Identifier><Identifier Source="GRID">grid.26999.3d</Identifier></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>01</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Cell Discov</MedlineTA><NlmUniqueID>101661034</NlmUniqueID><ISSNLinking>2056-5968</ISSNLinking></MedlineJournalInfo><CoiStatement>N.K., K.I., D.K., and K.M. have submitted a patent related to this work to the Japan Patent Office under application no. 2015-089220. 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sort="Isogaya, Kazunobu" uniqKey="Isogaya K" first="Kazunobu" last="Isogaya">Kazunobu Isogaya</name><name sortKey="Koinuma, Daizo" sort="Koinuma, Daizo" uniqKey="Koinuma D" first="Daizo" last="Koinuma">Daizo Koinuma</name><name sortKey="Miyazono, Kohei" sort="Miyazono, Kohei" uniqKey="Miyazono K" first="Kohei" last="Miyazono">Kohei Miyazono</name><name sortKey="Morikawa, Masato" sort="Morikawa, Masato" uniqKey="Morikawa M" first="Masato" last="Morikawa">Masato Morikawa</name><name sortKey="Morishita, Yasuyuki" sort="Morishita, Yasuyuki" uniqKey="Morishita Y" first="Yasuyuki" last="Morishita">Yasuyuki Morishita</name><name sortKey="Noda, Tetsuo" sort="Noda, Tetsuo" uniqKey="Noda T" first="Tetsuo" last="Noda">Tetsuo Noda</name><name sortKey="Taguchi, Luna" sort="Taguchi, Luna" uniqKey="Taguchi L" first="Luna" last="Taguchi">Luna Taguchi</name><name sortKey="Takano, Hiroshi" sort="Takano, Hiroshi" uniqKey="Takano H" first="Hiroshi" last="Takano">Hiroshi Takano</name><name sortKey="Yamori, Takao" sort="Yamori, Takao" uniqKey="Yamori T" first="Takao" last="Yamori">Takao Yamori</name><name sortKey="Yamori, Takao" sort="Yamori, Takao" uniqKey="Yamori T" first="Takao" last="Yamori">Takao Yamori</name><name sortKey="Yao, Ryoji" sort="Yao, Ryoji" uniqKey="Yao R" first="Ryoji" last="Yao">Ryoji Yao</name></country><country name="Suède"><region name="Svealand"><name sortKey="Morikawa, Masato" sort="Morikawa, Masato" uniqKey="Morikawa M" first="Masato" last="Morikawa">Masato Morikawa</name></region><name sortKey="Heldin, Carl Henrik" sort="Heldin, Carl Henrik" uniqKey="Heldin C" first="Carl-Henrik" last="Heldin">Carl-Henrik Heldin</name><name sortKey="Heldin, Carl Henrik" sort="Heldin, Carl Henrik" uniqKey="Heldin C" first="Carl-Henrik" last="Heldin">Carl-Henrik Heldin</name><name sortKey="Miyazono, Kohei" sort="Miyazono, Kohei" uniqKey="Miyazono K" first="Kohei" last="Miyazono">Kohei Miyazono</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix 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